Dr Artem Smirnov is Principal Investigator for the Understanding p63 destiny in bladder cancer
Biography
Dr Artem Smirnov received his PhD at University of Rome “Tor Vergata” in 2017. His PhD thesis was focused on understanding of epigenetic regulation of gene expression in human keratinocytes orchestrated by transcription factor p63, a member of the p53 family. After completing his PhD, Dr Smirnov worked as a postdoctoral fellow in Prof Xin Lu lab at University of Oxford (UK). During that period he studied interplay between p63 and iASPP in skin carcinogenesis as well as p53-dependent regulation of human oncogenic viruses such as EBV. Since 2022 he is a Researcher (RTDa) at University of Rome “Tor Vergata” in Prof Eleonora Candi’s lab, where he studies the role of p63 in regulation of bladder cancer
Representative Publications
Smirnov A., Lena A.M., Tosetti G., Yang X. et al. Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33 (2023) Cell Death Discovery. DOI: 10.1038/s41420-023-01716-3
Lena A.M., Rossi V., Osterburg S., Smirnov A. et al. The p63 C-terminus is essential for murine oocyte integrity (2021) Nature Communications. DOI: 10.1038/s41467-020-20669-0
Panatta E., Lena A.M., Mancini M., Smirnov A. et al. Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex (2020) EMBO Reports. DOI: 10.15252/embr.201846734
Smirnov A., Lena A.M., Cappello A., Panatta E. et al. ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development (2019) Oncogene. DOI: 10.1038/s41388-018-0509-4
Smirnov A., Cappello A., Lena A.M., Anemona L. et al. ZNF185 is a p53 target gene following DNA damage (2018) Aging. DOI: 10.18632/aging.101639