Alessia Angelin is Principal Investigator for the Metabolism in cancer
Biography
Dr. Alessia Angelin obtained her Master’s Degree in Biological Sciences from the University of Padua, Italy, with a thesis on the biochemical characterization of mitochondrial function under the supervision of Prof. Paolo Bernardi. Dr. Angelin has 15 years of international research experience in biochemistry and biomedical sciences, and her research primarily focuses on the physiology of mitochondria in human diseases. During these years, she worked as a postdoctoral scholar at the University of Padova, the University of California-Irvine (USA), and the Children’s Hospital of Philadelphia (USA) under the supervision of Prof. Douglas C. Wallace. She investigated the mitochondrial contribution to the pathophysiology of human cardiomyopathy and muscular dystrophy and recently developed an AAV-based gene therapy for treating human mitochondrial cardiac disorder. Over the years, her scientific interests have expanded to include the role of mitochondria in immune deficiencies and infection, metabolic diseases, and cancer. In 2024, she returned to Italy as an Assistant Professor in Biochemistry at the University of Rome Tor Vergata, School of Medicine. In Prof. Eleonora Candi’s laboratory, she studies the metabolic changes that occur in the transformation of neoplastic cells and tumor proliferation using cellular and murine models with biochemical techniques and omics characterization, with particular attention to the role of mitochondria. Currently, Dr. Angelin is mainly involved in two projects: (i) characterizing the role of p63 in regulating muscular differentiation and (ii) investigating the contribution of the polyol pathway in tumor development. Dr. Angelin has published 32 peer-reviewed articles and attended about 40 scientific conferences, several as an invited speaker.
Angelin A., Tiepolo T., Sabatelli P. [..] Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy. Novel therapeutic perspectives with cyclosporinsProc. Natl. Acad. Sci. USA 2007
Merlini L., Angelin A., Tiepolo T. [..] Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathiesProc. Natl. Acad. Sci. USA 2008
Angelin A., Gil-de-Gomez L., Dahiya S., Jiao J. […] Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environment Cell Metabolism 2017
Bertholet AM., Chouchani ET., Kazak L., Angelin A. […] H+ transport is an integral function of the mitochondrial ADP/ATP carrier Nature 2019
Angelin A. Cyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism Cell Death & Disease. 2023