Eleonora Candi is Principal Investigator for the Epigenetic regulation mediated by p63 in epithelial tumours
Biography
Eleonora Candi is Professor of Molecular Biology, at the University of Rome Tor Vergata. Eleonora received her Ph.D. in Biochemistry of the Epithelia in 1995 (Rome, Italy). She did her pre- and post-doctoral training (1993-1998) at the Skin Biology Branch, NIAMS, National Institute of Health, Bethesda, MD, USA, working on transglutaminases and their substrates. After, she became Associate (2003) and Full (2017) Professor in Molecular Biology at the Faculty of Medicine of the University of Rome Tor Vergata. She is editorial board member of (i) Cell Death & Disease (IF= 6,2); (ii) The FEBS Journal (IF=4,7). She is the coordinator of the PhD program in “Biochemistry and Molecular Biology” and of the master degree in “Nutrition and Cosmetics”. She is also responsible for research granted by the Ministry of Health at the IDI-IRCCS hospital (Rome). She has been working on cell death, both apoptosis and keratinization in the past years (H-index 45, cites 10428). Her current scientific interest is the role of p63, homolog of p53, in epithelia development and tumour formation, affecting epigenetic modifications, miRNAs and lncRNAs.
Representative Publications
Panatta E, et al. Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex. EMBO Reports. 2020;21(3):e46734.
Smirnov A, et al. ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development. Oncogene. 2019;38(10):1625-1638.
Viticchiè G, et al. p63 supports aerobic respiration through hexokinase II. PNAS- USA 2015;112(37):11577-82.
Candi E, et al. MicroRNAs and p63 in epithelial stemness. Cell Death Differ. 2015;22(1):12-21.
Amelio I, et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biol. 2012 Oct 15;199(2):347-63.