Prof. Mauro Piacentini

Mauro Piacentini is Principal Investigator for the Cell Death and Autophagy Mechanisms

Prof. Mauro Piacentini is Full Professor of Cellular and Developmental Biology at University of Rome “Tor Vergata”, Rome. Basic Research Director at the National Institute for Infectious Diseases IRCCS “Lazzaro Spallanzani” in Rome. Co-Founder and Editor-in-Chief of Cell Death & Disease and Senior Editor of Cell Death & Differentiation. President of the National Research Committee the Ministry of Health. His scientific interest (H-index 85; Citations 42000) focuses on the molecular mechanisms regulating cell death and autophagy both under physiological and pathological conditions (cancer and infectious diseases) with particular regard to the biological role of Type 2 Transglutaminase and Ambra1.

Representative Publications
Fimia GM, et al. Ambra1 regulates autophagy and development of the nervous system.
Nature 447(7148):1121-5, 2007.
Antonioli M, et al. AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics. Developmental Cell 31(6):734-46, 2014.
Rossin F, et al. TG2 regulates the heat-shock response by the post-translational modification of HSF1. EMBO Report 19(7). pii: e45067, 2018.
D’Eletto M, et al. Transglutaminase Type2 regulates ER-Mitochondria contact sites by interacting with GRP75. Cell Report 25(13):3573-3581, 2018.
Di Rienzo M, et al. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. Science Advances 5(5):eaau8857, 2019.